Structure of PDB 8r32 Chain A

Receptor sequence
>8r32A (length=253) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NRSLIVTTILEEPYVLFKKSLYGNDRFEGYCIDLLRELSTILGFTYEIRL
VEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP
FMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTY
DKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNL
TQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN
GCP
3D structure
PDB8r32 The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.
ChainA
Resolution1.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y488 P516 A518 R523 G688 A689 T690 E738 Y56 P84 A86 R91 G136 A137 T138 E186
BS02 2J9 A K531 P532 F533 M534 T535 L783 Q786 K99 P100 F101 M102 T103 L231 Q234
External links
PDB RCSB:8r32, PDBe:8r32, PDBj:8r32
PDBsum8r32
PubMed38369668
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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