Structure of PDB 8qzz Chain A

Receptor sequence
>8qzzA (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
LGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVK
AISGVHTKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKG
NFKLVRHVSFVDCPLMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAA
IEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISA
QLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKG
GVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHN
DLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYF
LLRRLLGQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVG
EKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDD
3D structure
PDB8qzz Substrate recruitment via eIF2g enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response
ChainA
Resolution3.35 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S171 E178 T214 L377 L378 R379 R380 L382 Q396 S145 E152 T188 L351 L352 R353 R354 L356 Q358
BS02 GNP A A51 G53 K54 S55 T56 N190 K191 D193 Q227 A42 G44 K45 S46 T47 N164 K165 D167 Q201
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, RNA binding
GO:0016787 hydrolase activity
GO:0045296 cadherin binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8qzz, PDBe:8qzz, PDBj:8qzz
PDBsum8qzz
PubMed38547060
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

[Back to BioLiP]