Structure of PDB 8qz8 Chain A

Receptor sequence

>8qz8A (length=417) Species: 1549864 (Tilapia lake virus) [Search protein sequence]

MDSRFAQLTGVFCDDFTYSEGSRRFLSSYSTVERRPGVPVEGDCYDCLKN
KWIAFELEGQPRKFPKATVRCILNNDATYVCSEQEYQQICKVQFKDYLEI
DGVVKVGHKASYDAELRERLLELPHPKSGPKPRIEWVAPPRLADISKETA
ELKRQYGFFECSKFLACGEECGLDQEARELILNEYARDREFEFRNGGWIQ
RYTVASHKPATQKILPLPASAPLARELLMLIARSTTQAGKVLHSDNTSIL
AVPVMRDSGKHSKRRPTASTHHLVVGLSKPGCEHDFEFDGYRAAVHVMHL
DPKQSANIGEQDFVSTREIYKLDMLELPPISRKGDLDRASGLETRWDVIL
LLECLDSTRVSQAVAQHFNRHRLALSVCKDEFRKGYQLASEIRGTIPLSS
LYYSLCAVRLRMTVHPF

3D structure

PDB

8qz8 Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.

Chain

Resolution

3.13 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Q175 Y202 S206 H207 K208 A210 M229 R233 T236 Q237 S244 D245 V254 R256 K263 R265 T267 S269 T270 H271 H272 M298 H299 L300 Q304 L355 S357 R393 G394 P397	Q175 Y202 S206 H207 K208 A210 M229 R233 T236 Q237 S244 D245 V254 R256 K263 R265 T267 S269 T270 H271 H272 M298 H299 L300 Q304 L355 S357 R393 G394 P397
BS02	ZN	A	C161 C282 H284 H296	C161 C282 H284 H296

External links

PDB	RCSB:8qz8, PDBe:8qz8, PDBj:8qz8
PDBsum	8qz8
PubMed	38066000
UniProt	A0A142I7Z3

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