Structure of PDB 8qz4 Chain A

Receptor sequence
>8qz4A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
VMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRD
HVCVSPQELETLIQHALDADNAGVSPIGNSSHWDLGSAFFFAGTVITTIG
YGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVER
VISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDF
VAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEE
3D structure
PDB8qz4 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A V251 F252 F260 L304 F307 V164 F165 F173 L217 F220
BS02 Y01 A V83 L330 S331 V13 L243 S244
BS03 Y01 A L191 F195 L117 F121
External links
PDB RCSB:8qz4, PDBe:8qz4, PDBj:8qz4
PDBsum8qz4
PubMed38755204
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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