Structure of PDB 8qz2 Chain A

Receptor sequence
>8qz2A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
MKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVC
VSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTI
GYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVE
KVRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGF
GDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMI
3D structure
PDB8qz2 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A G174 Y175 G176 G283 F284 G285 G101 Y102 G103 G199 F200 G201
BS02 K A I173 G174 Y175 V282 G283 F284 I100 G101 Y102 V198 G199 F200
BS03 K A T172 I173 T281 V282 T99 I100 T197 V198
BS04 K A T172 T281 T99 T197
External links
PDB RCSB:8qz2, PDBe:8qz2, PDBj:8qz2
PDBsum8qz2
PubMed38755204
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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