Structure of PDB 8qz1 Chain A

Receptor sequence
>8qz1A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGNSHWDLGSAFFFAGTVITTIGYGN
IAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSQTKIRVIST
ILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGG
YREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEV
3D structure
PDB8qz1 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
ChainA
Resolution3.588 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A I173 G174 Y175 V282 G283 F284 I96 G97 Y98 V191 G192 F193
BS02 K A T172 I173 T281 V282 G283 T95 I96 T190 V191 G192
BS03 K A T172 T281 T95 T190
External links
PDB RCSB:8qz1, PDBe:8qz1, PDBj:8qz1
PDBsum8qz1
PubMed38755204
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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