Structure of PDB 8qyw Chain A

Receptor sequence
>8qywA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
EAFEETHLTSLDPVKQFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSAR
MLLLKGFGKDGFRFFTNFESRKGKELDSNPFASLVFYWEPLNRQVRVEGP
VKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPDREYLRKKNEELEQLY
QDQEVPKPKSWGGYVLYPQVMEFWQGQTNHLHDRIVFRRLGPMTHRGEED
WLYERLAP
3D structure
PDB8qyw Identification of the pyridoxal 5'-phosphate allosteric site in human pyridox(am)ine 5'-phosphate oxidase.
ChainA
Resolution2.746 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.3.5: pyridoxal 5'-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A S115 R116 K119 S70 R71 K74
BS02 FMN A R95 M96 L97 T111 S115 R116 K117 Q174 S175 R50 M51 L52 T66 S70 R71 K72 Q129 S130
BS03 PO4 A R161 S165 R116 S120
Gene Ontology
Molecular Function
GO:0004733 pyridoxamine phosphate oxidase activity
GO:0005515 protein binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0008615 pyridoxine biosynthetic process
GO:0042816 vitamin B6 metabolic process
GO:0042818 pyridoxamine metabolic process
GO:0042822 pyridoxal phosphate metabolic process
GO:0042823 pyridoxal phosphate biosynthetic process
GO:1901615 organic hydroxy compound metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:8qyw, PDBe:8qyw, PDBj:8qyw
PDBsum8qyw
PubMed38284493
UniProtQ9NVS9|PNPO_HUMAN Pyridoxine-5'-phosphate oxidase (Gene Name=PNPO)

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