Structure of PDB 8qyu Chain A

Receptor sequence
>8qyuA (length=768) Species: 9913 (Bos taurus) [Search protein sequence]
DAEMAAFGEAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKATIL
SREGGKVTAETEHGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVL
YNLKERYASWMIYTYSGLFCVTINPYKWLPVYNAEVVAAYRGKKRSEAPP
HIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIT
LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIET
YLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQ
GETTVASIDDAEELMATDNAFDVLGFTTEEKNSMYKLTGAIMHFGNMKFK
LKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQ
NVQQVVYAKGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGF
EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGM
DLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSSNFQK
PRNIKGKPEAHFSLIHYAGTVDYNIIGWLQKNKDPLNETVVDLYKKSSLK
MLSSLFAQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDNP
LVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPDSRKGA
EKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQS
RGVLSRMEFKKLLERRDS
3D structure
PDB8qyu Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N126 P127 G181 G183 K184 T185 V186 N238 N124 P125 G179 G181 K182 T183 V184 N223
BS02 MG A T185 S242 T183 S227
BS03 2OW A R147 Y164 T167 D168 H666 P710 N711 R712 Y722 L770 E774 R145 Y162 T165 D166 H629 P673 N674 R675 Y685 L728 E732
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8qyu, PDBe:8qyu, PDBj:8qyu
PDBsum8qyu
PubMed38014327
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

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