Structure of PDB 8qws Chain A

Receptor sequence
>8qwsA (length=286) Species: 67327 (Streptomyces melanosporofaciens) [Search protein sequence]
DIGRSSVRPYLEECTRRFQEMFDRHVVTRPTKVELTDAELREVIDDCNAA
VAPLGKTVSDERWISYVGLVLWSQSPRHIKDMEAFKAVCVLNCVTFVWDD
MDPALHDFGLFLPQLRKICEKYYGPEDAEVAYEAARAFVTSDHMFRDSPI
KAALCTTSPEQYFRFRVTDIGVDFWMKMSYPIYRHPEFTEHAKTSLAARM
TTRGLTIVNDFYSYDREVSLGQITNCFRLCDVSDETAFKEFFQARLDDMI
EDIECIKAFDQLTQDVFLDLIYGNFVWTTSNKRYKT
3D structure
PDB8qws Crystal structure of CotB2 variant V80L in complex with alendronate
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.3.146: cyclooctat-9-en-7-ol synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AHD A F107 D110 R177 I181 N220 S224 R227 E228 R294 Y295 F96 D99 R166 I170 N209 S213 R216 E217 R283 Y284
BS02 MG A N220 S224 E228 N209 S213 E217
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8qws, PDBe:8qws, PDBj:8qws
PDBsum8qws
PubMed
UniProtC9K1X5|COTB2_STRMJ Cyclooctat-9-en-7-ol synthase (Gene Name=CotB2)

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