Structure of PDB 8qwa Chain A

Receptor sequence
>8qwaA (length=406) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
MADVVVGIQWGDEGKGKIVDRIAKDYDFVVRYQGGHNAGHTIVHKGVKHS
LHLMPSGVLYPKCKNIISSAVVVSVKDLCEEISAFEDLENRLFVSDRAHV
ILPYHAKKDAFKEKSQNIGTTKKGIGPCYEDKMARSGIRMGDLLDDKILE
EKLNAHFKAIEPFKKAYDLGENYEKDLMGYFKTYAPKICPFIKDTTSMLI
EANQKGEKILLEGAQGTLLDIDLGTYPFVTSSNTTSASACVSTGLNPKAI
NEVIGITKAYSTRVGNGPFPSEDTTPMGDHLRTKGAEKRPRRCGWLDLVA
LKYACALNGCTQLALMKLDVLDGIDAIKVCVAYERKGERLEIFPSDLKDC
VPIYQTFKGWEKSVGVRKLDDLEPNVREYIRFIEKEVGVKIRLISTSPER
EDTIFL
3D structure
PDB8qwa Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains.
ChainA
Resolution1.85 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A D12 N37 G119 T120 T121 Q215 L219 V229 T230 V264 R294 D12 N37 G119 T120 T121 Q215 L219 V229 T230 V264 R289
BS02 PLP A D12 G14 K15 G16 H40 K322 D12 G14 K15 G16 H40 K317
External links
PDB RCSB:8qwa, PDBe:8qwa, PDBj:8qwa
PDBsum8qwa
PubMed39149761
UniProtP56137|PURA_HELPY Adenylosuccinate synthetase (Gene Name=purA)

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