Structure of PDB 8qw7 Chain A

Receptor sequence
>8qw7A (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
EYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCL
LDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
VKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGV
DDAFYTLVREIRKHKE
3D structure
PDB8qw7 Targeting cancer with small molecule pan-KRAS degraders
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X53 A E62 E63 Y64 M72 H95 Y96 Q99 E60 E61 Y62 M70 H93 Y94 Q97
BS02 GDP A V12 G13 G15 K16 S17 A18 D30 N116 K117 D119 A146 V10 G11 G13 K14 S15 A16 D28 N114 K115 D117 A144
BS03 MG A S17 P34 S15 P32
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8qw7, PDBe:8qw7, PDBj:8qw7
PDBsum8qw7
PubMed
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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