Structure of PDB 8qvu Chain A
Receptor sequence
>8qvuA (length=155) Species:
9606
(Homo sapiens) [
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TEYKLVVVGADGVGKSALTIQLIQNHFVDEDPTIEDSYRKQDGETDILDT
AGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSED
VPMVLVGDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGDDAFYTLVRE
IRKHK
3D structure
PDB
8qvu
Targeting cancer with small molecule pan-KRAS degraders
Chain
A
Resolution
2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
3.6.5.2
: small monomeric GTPase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
WYL
A
V9 E62 E63 Y64 D69 M72 D92 H95 Y96 E98 Q99 R102
V8 E54 E55 Y56 D61 M64 D84 H87 Y88 E90 Q91 R94
BS02
GDP
A
D12 G13 G15 K16 S17 A18 F28 D30 D119 S145 A146 K147
D11 G12 G14 K15 S16 A17 F27 D29 D108 S134 A135 K136
BS03
MG
A
S17 D57
S16 D49
Gene Ontology
Molecular Function
GO:0003924
GTPase activity
GO:0003925
G protein activity
GO:0005515
protein binding
GO:0005525
GTP binding
GO:0016787
hydrolase activity
GO:0019003
GDP binding
GO:0043495
protein-membrane adaptor activity
GO:0044877
protein-containing complex binding
Biological Process
GO:0000165
MAPK cascade
GO:0001934
positive regulation of protein phosphorylation
GO:0007165
signal transduction
GO:0007265
Ras protein signal transduction
GO:0008283
cell population proliferation
GO:0008542
visual learning
GO:0010467
gene expression
GO:0010628
positive regulation of gene expression
GO:0014009
glial cell proliferation
GO:0016601
Rac protein signal transduction
GO:0021897
forebrain astrocyte development
GO:0030036
actin cytoskeleton organization
GO:0030857
negative regulation of epithelial cell differentiation
GO:0032228
regulation of synaptic transmission, GABAergic
GO:0035022
positive regulation of Rac protein signal transduction
GO:0035914
skeletal muscle cell differentiation
GO:0043524
negative regulation of neuron apoptotic process
GO:0048169
regulation of long-term neuronal synaptic plasticity
GO:0048873
homeostasis of number of cells within a tissue
GO:0051146
striated muscle cell differentiation
GO:0051402
neuron apoptotic process
GO:0060252
positive regulation of glial cell proliferation
GO:0060441
epithelial tube branching involved in lung morphogenesis
GO:0060509
type I pneumocyte differentiation
Cellular Component
GO:0000139
Golgi membrane
GO:0005737
cytoplasm
GO:0005741
mitochondrial outer membrane
GO:0005789
endoplasmic reticulum membrane
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0005925
focal adhesion
GO:0009898
cytoplasmic side of plasma membrane
GO:0012505
endomembrane system
GO:0016020
membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8qvu
,
PDBe:8qvu
,
PDBj:8qvu
PDBsum
8qvu
PubMed
UniProt
P01116
|RASK_HUMAN GTPase KRas (Gene Name=KRAS)
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