Structure of PDB 8qug Chain A

Receptor sequence
>8qugA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB8qug Targeting cancer with small molecule pan-KRAS degraders
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G14 V15 G16 K17 S18 A19 F29 D31 N117 K118 D120 L121 S146 A147
BS02 WYU A V9 E62 E63 D69 M72 H95 Y96 V10 E63 E64 D70 M73 H96 Y97
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8qug, PDBe:8qug, PDBj:8qug
PDBsum8qug
PubMed
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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