Structure of PDB 8qtj Chain A

Receptor sequence
>8qtjA (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLR
LILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQ
SQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFF
GDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIF
TRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFR
LSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRS
YNPDLTGLCEKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMC
TSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
3D structure
PDB8qtj Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
ChainA
Resolution1.523 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C373 C376 C393 C396 C330 C333 C350 C353
BS02 ZN A C388 H390 C408 C411 C345 H347 C365 C368
BS03 WUI A R141 T144 K145 L148 S218 T219 L222 Y260 A262 F263 L264 L287 Y363 M366 R105 T108 K109 L112 S182 T183 L186 Y224 A226 F227 L228 L251 Y320 M323
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:8qtj, PDBe:8qtj, PDBj:8qtj
PDBsum8qtj
PubMed38227216
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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