Structure of PDB 8qtg Chain A

Receptor sequence
>8qtgA (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLR
LILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQ
SQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFF
GDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIF
TRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFR
LSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRS
YNPDLTGLCEKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMC
TSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
3D structure
PDB8qtg Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
ChainA
Resolution1.419 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WUQ A R141 T144 K145 L148 S218 T219 Y260 A262 F263 L287 Y363 M366 R105 T108 K109 L112 S182 T183 Y224 A226 F227 L251 Y320 M323
BS02 ZN A C373 C376 C393 C396 C330 C333 C350 C353
BS03 ZN A C388 H390 C408 C411 C345 H347 C365 C368
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:8qtg, PDBe:8qtg, PDBj:8qtg
PDBsum8qtg
PubMed38227216
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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