Structure of PDB 8qt9 Chain A

Receptor sequence

>8qt9A (length=399) Species: 1313 (Streptococcus pneumoniae)

EFSMKSVKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFILATR
LPLLESWFHSLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGN
LAIYIFASIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRL
LTFNLLSFLVGSYALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTR
EIQIHLSRPFNYQSGQFAFLKIFQEGFESAPHPFSISGGHGQTLYFTVKT
SGDHTKNIYDNLQAGSKVTLDRAYGHMIIEEGRENQVWIAGGIGITPFIS
YIREHPILDKQVHFYYSFRGDENAVYLDLLRNYAQKNPNFELHLIDSTKD
GYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEGFKFK

3D structure

• PDB: 8qt9 Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase.
• Chain: A
• Resolution: 2.36 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	Y122 F218 H233 P234 F235 S236 V249 S252 G253 D254 H255 T256 I294 T297 F397	Y121 F217 H232 P233 F234 S235 V248 S251 G252 D253 H254 T255 I293 T296 F396
BS02	HEM	A	T45 F46 A49 R51 Y66 H69 K70 A73 I111 Y122 R126 H129 R130 V132 I175 K400	T44 F45 A48 R50 Y65 H68 K69 A72 I110 Y121 R125 H128 R129 V131 I174 K399
BS03	HEM	A	F32 P35 L39 L80 H83 N84 G88 A97 G100 N101 A103 F107 H142 I143 I146	F31 P34 L38 L79 H82 N83 G87 A96 G99 N100 A102 F106 H141 I142 I145
BS04	NAI	A	K250 G292 I294 G295 S318 F319 R320 S348 Y353 G371 P372 S374 M375 E395 G396 F397	K249 G291 I293 G294 S317 F318 R319 S347 Y352 G370 P371 S373 M374 E394 G395 F396

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8qt9, PDBe:8qt9, PDBj:8qt9
• PDBsum: 8qt9
• PubMed: 39039317
• UniProt: Q8CZ28