Structure of PDB 8qm3 Chain A

Receptor sequence

>8qm3A (length=574) Species: 1501 (Clostridium pasteurianum) [Search protein sequence]

MKTIIINGVQFNTDEDTTILKFARDNNIDISALCFLNNCNNDINKCEICT
VEVEGTGLVTACDTLIEDGMIINTNSDAVNEKIKSRISQLLDIHEFKCGP
CNRRENCEFLKLVIKYKARASKPFLPKDKTEYVDERSKSLTVDRTKCLLC
GRCVNACGKNTETYAMKFLNKNGKTIIGAEDEKCFDDTNCLLCGQCIIAC
PVAALSEKSHMDRVKNALNAPEKHVIVAMAPSVRASIGELFNMGFGVDVT
GKIYTALRQLGFDKIFDINFGADMTIMEEATELVQRIENNGPFPMFTSCC
PGWVRQAENYYPELLNNLSSAKSPQQIFGTASKTYYPSISGLDPKNVFTV
TVMPCTSKKFEADRPQMEKDGLRDIDAVITTRELAKMIKDAKIPFAKLED
SEADPAMGEYSGAGAIFGATGGVMEAALRSAKDFAENAELEDIEYKQVRG
LNGIKEAEVEINNNKYNVAVINGASNLFKFMKSGMINEKQYHFIEVMACH
GGCVNGGGQPHVNPKDLEKVDIKKVRASVLYNQDEHLSKRKSHENTALVK
MYQNYFGKPGEGRAHEILHFKYKK

3D structure

PDB

8qm3 Insights into the Molecular Mechanism of Formaldehyde Inhibition of [FeFe]-Hydrogenases

Chain

Resolution

1.53 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.12.7.2: ferredoxin hydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	402	A	A230 P231 S232 C299 P324 Q325 M353 P354 K358 F417 M497 C503	A230 P231 S232 C299 P324 Q325 M353 P354 K358 F417 M497 C503
BS02	SF4	A	C300 C355 M497 A498 C499 C503	C300 C355 M497 A498 C499 C503
BS03	SF4	A	C157 T161 A165 M166 C190 L191 L192 C193 G194 C196	C157 T161 A165 M166 C190 L191 L192 C193 G194 C196
BS04	SF4	A	C147 L148 L149 C150 G151 C153 I177 C200 P201 A204 L205	C147 L148 L149 C150 G151 C153 I177 C200 P201 A204 L205
BS05	SF4	A	H94 F96 K97 C98 C101 C107 K146 V202 A203	H94 F96 K97 C98 C101 C107 K146 V202 A203
BS06	FES	A	A32 C34 F35 C46 E47 C49 C62	A32 C34 F35 C46 E47 C49 C62
BS07	MG	A	N40 D42	N40 D42

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0008901	ferredoxin hydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

View graph for
Molecular Function

External links

PDB	RCSB:8qm3, PDBe:8qm3, PDBj:8qm3
PDBsum	8qm3
PubMed	37983562
UniProt	P29166\|PHF1_CLOPA Iron hydrogenase 1

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