Structure of PDB 8qk2 Chain A

Receptor sequence
>8qk2A (length=230) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
ATLFIADLHLQTEEPEITAGFLRFLQGEARQADALYILGDLFEAWIGDDD
PNPLHQQIASAIKAVVDAGVPCYFIHGNRDFLVGQRFARQSGMILLAEEE
RLDLYGREVLIMHGDTLCTDDQGYLAFRAKVHTPWIQRLFLALPLFIRHR
IAARMRAEIMDVNPQAVVDAMERHHVQWLIHGHTHRPAVHELQANGQPAW
RVVLGAWHSEGSMVKVTPDDVELIHFPFHH
3D structure
PDB8qk2 Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D8 H10 D41 H197 D7 H9 D40 H185
BS02 MN A D41 N79 H114 H195 D40 N78 H113 H183
BS03 VTF A A45 W46 N79 R80 F82 Y125 F128 F141 M156 A44 W45 N78 R79 F81 Y124 F127 F140 M155
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qk2, PDBe:8qk2, PDBj:8qk2
PDBsum8qk2
PubMed38579010
UniProtA6T5R0|LPXH_KLEP7 UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

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