Structure of PDB 8qjz Chain A

Receptor sequence
>8qjzA (length=239) Species: 562 (Escherichia coli) [Search protein sequence]
ATLFIADLHLCVEEPAITAGFLRFLAEEARKADALYILGDLFEAWIGDDD
PNPLHRQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEK
VLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQMLFLALPLFVRKR
IAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAV
HELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
3D structure
PDB8qjz Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D8 H10 D41 H197 D7 H9 D40 H196
BS02 MN A D41 N79 H114 H195 D40 N78 H113 H194
BS03 LP5 A N79 R80 L83 Y125 L137 F141 M156 R157 N159 S160 N164 K167 H195 N78 R79 L82 Y124 L136 F140 M155 R156 N158 S159 N163 K166 H194
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qjz, PDBe:8qjz, PDBj:8qjz
PDBsum8qjz
PubMed38579010
UniProtA0A066QL39

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