Structure of PDB 8qjt Chain A

Receptor sequence
>8qjtA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
PPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPV
DFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQS
VFKSARQKIAKEE
3D structure
PDB8qjt PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
ChainA
Resolution2.568 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VLC A V1408 F1409 Q1411 L1412 P1413 E1417 Y1421 V1429 A1460 F1463 N1464 I1470 V29 F30 Q32 L33 P34 E38 Y42 V50 A81 F84 N85 I91
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8qjt, PDBe:8qjt, PDBj:8qjt
PDBsum8qjt
PubMed38180485
UniProtP51531|SMCA2_HUMAN Probable global transcription activator SNF2L2 (Gene Name=SMARCA2)

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