Structure of PDB 8qhr Chain A

Receptor sequence
>8qhrA (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
MGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTQHVAAAGDRLIHE
QDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFRPQSGRVLS
AMIRGAADGSRFQVWDYEEGEVEALLDRYFEA
3D structure
PDB8qhr Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3DR A C26 G27 S28 I29 R30 G31 D80 S98 G100 E104 C9 G10 S11 I12 R13 G14 D52 S70 G72 E76
BS02 3DR A S128 M130 S100 M102
Gene Ontology
Molecular Function
GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Biological Process
GO:0009159 deoxyribonucleoside monophosphate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8qhr, PDBe:8qhr, PDBj:8qhr
PDBsum8qhr
PubMed37884503
UniProtO43598|DNPH1_HUMAN 5-hydroxymethyl-dUMP N-hydrolase (Gene Name=DNPH1)

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