Structure of PDB 8qg0 Chain A

Receptor sequence

>8qg0A (length=427) Species: 2234 (Archaeoglobus fulgidus)

MMEYKIVENGLTYRIGNGASVPISNTGELIKGLRNYGPYEVPSLKYNQIA
LIHNNQFSSLINQLKSQISSKIDEVWHIHNINISEFIYDSPHFDSIKSQV
DNAIDTGVDGIMLVLPEYNTPLYYKLKSYLINSIPSQFMRYDILSNRNLT
FYVDNLLVQFVSKLGGKPWILNVDPEKGSDIIIGTGATRIDNVNLFCFAM
VFKKDGTMLWNEISPIVTSSEYLTYLKSTIKKVVYGFKKSNPDWDVEKLT
LHVSGKRPKMKDGETKILKETVEELKKQEMVSRDVKYAILHLNETHPFWV
MGDPNNRFHPYEGTKVKLSSKRYLLTLLQPYLKRNGLEMVTPIKPLSVEI
VSDNWTSEEYYHNVHEILDEIYYLSKMNWRGFRSRNLPVTVNYPKLVAGI
IANVNRYGGYPINPEGNRSLQTNPWFL

3D structure

• PDB: 8qg0 The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein.
• Chain: A
• Resolution: 3.43 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	T26 G27 F151 D154 T188 R189 G255 H291 N293 T295 H296 P297 R322 K333	T26 G27 F151 D154 T188 R189 G255 H291 N293 T295 H296 P297 R322 K333
BS02	rna	A	N119 T120 Y123 K127 F138 I143 Y152 N155 L156 Q159 R189 N192 R257 K259 M260 L328 T341 P342 I343 K344 R380 R383 S384 R385 L427	N119 T120 Y123 K127 F138 I143 Y152 N155 L156 Q159 R189 N192 R257 K259 M260 L328 T341 P342 I343 K344 R380 R383 S384 R385 L427

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0046872 metal ion binding

External links

• PDB: RCSB:8qg0, PDBe:8qg0, PDBj:8qg0
• PDBsum: 8qg0
• PubMed: 38197228
• UniProt: O28951|PIWI_ARCFU Piwi protein (Gene Name=AF_1318)