Structure of PDB 8qez Chain A

Receptor sequence
>8qezA (length=264) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKL
KNKWWYDKGECGSG
3D structure
PDB8qez Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y61 T91 R96 G141 S142 T143 E193 Y61 T91 R96 G141 S142 T143 E193
BS02 ZN A H23 E24 H23 E24
BS03 ZN A E42 H46 E42 H46
BS04 UF5 A K104 P105 F106 M107 S108 L239 S242 K104 P105 F106 M107 S108 L239 S242
BS05 UF5 A P105 S108 S217 K218 G219 P105 S108 S217 K218 G219
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8qez, PDBe:8qez, PDBj:8qez
PDBsum8qez
PubMed38101041
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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