Structure of PDB 8qee Chain A

Receptor sequence
>8qeeA (length=823) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSK
NSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFIT
EELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQEC
GKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEE
RLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLYAT
WALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPF
LILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLC
QTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSN
YKQFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQD
SYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSL
ANVLEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSF
PSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPY
STALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFA
YSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVV
TMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSE
TKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRM
WFTLIIVAALHALLFLPALLSLF
3D structure
PDB8qee Conformational changes in the Niemann-Pick Type C1 protein NCR1 drive sterol translocation through the glycocalyx
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A W370 L548 I616 Q776 V793 F962 F987 F990 F991 W47 L225 I293 Q443 V460 F629 F654 F657 F658
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8qee, PDBe:8qee, PDBj:8qee
PDBsum8qee
PubMed38568972
UniProtQ12200|NPC1_YEAST NPC intracellular sterol transporter 1-related protein 1 (Gene Name=NCR1)

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