Structure of PDB 8qec Chain A

Receptor sequence
>8qecA (length=1101) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKE
VRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGR
FVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMD
LIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEV
YACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICA
LFAFMWYYLVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFS
IFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIF
VVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCV
IESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDD
ILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISL
EKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLAS
IVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKP
EYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTV
SVIFNGVLQLTAYVSILSLYEKRSNYKQITSFLKTFYFKMLTQKRLIIII
FSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYM
VVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLD
DYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFP
EGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHP
LRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLI
GSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVS
LVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIK
GITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSL
F
3D structure
PDB8qec Conformational changes in the Niemann-Pick Type C1 protein NCR1 drive sterol translocation through the glycocalyx
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A W370 L548 I616 P986 F990 I1125 W322 L500 I568 P931 F935 I1070
BS02 ERG A K90 F109 F112 T113 L171 K70 F89 F92 T93 L151
BS03 Q7G A E450 Q485 Q486 L510 P932 E402 Q437 Q438 L462 P877
BS04 Y01 A L767 I770 G998 T1001 L1002 I1005 L712 I715 G943 T946 L947 I950
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8qec, PDBe:8qec, PDBj:8qec
PDBsum8qec
PubMed38568972
UniProtQ12200|NPC1_YEAST NPC intracellular sterol transporter 1-related protein 1 (Gene Name=NCR1)

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