Structure of PDB 8qeb Chain A

Receptor sequence
>8qebA (length=1098) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKE
VRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGR
FVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMD
LIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEV
YACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICA
LFAFMWYYLVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFS
IFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIF
VVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCV
IESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDD
ILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISL
EKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLAS
IVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKP
EYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTV
SVIFNGVLQLTAYVSILSLYEKRSNYKQILKTFYFKMLTQKRLIIIIFSA
WFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVK
NLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYF
MFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGK
DFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRS
QKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSA
IILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVN
LIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGIT
LTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLF
3D structure
PDB8qeb Conformational changes in the Niemann-Pick Type C1 protein NCR1 drive sterol translocation through the glycocalyx
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A W370 L552 E619 L774 Q776 V1054 I1125 W322 L504 E571 L716 Q718 V996 I1067
BS02 ERG A N87 K90 F109 L186 S196 N67 K70 F89 L166 S176
BS03 Y01 A L767 I770 T1001 L1002 I1005 G1006 I1010 T1034 V1038 G1041 L709 I712 T943 L944 I947 G948 I952 T976 V980 G983
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8qeb, PDBe:8qeb, PDBj:8qeb
PDBsum8qeb
PubMed38568972
UniProtQ12200|NPC1_YEAST NPC intracellular sterol transporter 1-related protein 1 (Gene Name=NCR1)

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