Structure of PDB 8qe3 Chain A

Receptor sequence
>8qe3A (length=382) Species: 9606 (Homo sapiens) [Search protein sequence]
EEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTG
MILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQ
SPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAK
LAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEV
CLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTG
RKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRR
VLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRD
LDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
3D structure
PDB8qe3 Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
ChainA
Resolution1.089 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U96 A F18 F20 Q190 G193 V195 W274 R313 F5 F7 Q177 G180 V182 W261 R300
BS02 SAM A H29 P30 D179 K181 S247 F250 D258 H16 P17 D166 K168 S234 F237 D245
Gene Ontology
Molecular Function
GO:0004478 methionine adenosyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0034214 protein hexamerization
GO:0051291 protein heterooligomerization
GO:0061431 cellular response to methionine
GO:1904263 positive regulation of TORC1 signaling
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol
GO:0048269 methionine adenosyltransferase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8qe3, PDBe:8qe3, PDBj:8qe3
PDBsum8qe3
PubMed38466661
UniProtP31153|METK2_HUMAN S-adenosylmethionine synthase isoform type-2 (Gene Name=MAT2A)

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