Structure of PDB 8qd0 Chain A

Receptor sequence
>8qd0A (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
IKVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLS
MCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLF
PVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIA
IGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPK
YPPSRAQSLSYALTASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTL
LNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLV
VYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELT
YPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLG
AALTAFIKADLRRQKANKETLE
3D structure
PDB8qd0 Cryo-EM structure of the inward-facing choline-bound FLVCR2
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CHT A W102 M131 Q191 Y325 Q447 W25 M54 Q114 Y245 Q367
Gene Ontology
Molecular Function
GO:0015220 choline transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0020037 heme binding
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0015871 choline transport
GO:0034229 ethanolamine transport
GO:0055085 transmembrane transport
GO:0097037 heme export
GO:0150104 transport across blood-brain barrier
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8qd0, PDBe:8qd0, PDBj:8qd0
PDBsum8qd0
PubMed38778100
UniProtQ9UPI3|FLVC2_HUMAN Heme transporter FLVCR2 (Gene Name=FLVCR2)

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