Structure of PDB 8qct Chain A

Receptor sequence
>8qctA (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
LTALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWL
SMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKCGSVQQHL
FWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGT
AVGFLLPPVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILTAIAFKEK
PRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFY
SVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYK
QTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLGFEF
AVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCV
WMFIGIILTALIKSDLRR
3D structure
PDB8qct Cryo-EM structure of the inward-facing choline-bound FLVCR1
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CHT A W125 Q214 Y349 Q471 W26 Q115 Y250 Q372
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015220 choline transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0020037 heme binding
GO:0022857 transmembrane transporter activity
GO:0034228 ethanolamine transmembrane transporter activity
Biological Process
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0006783 heme biosynthetic process
GO:0006839 mitochondrial transport
GO:0006879 intracellular iron ion homeostasis
GO:0008654 phospholipid biosynthetic process
GO:0015871 choline transport
GO:0015886 heme transport
GO:0030218 erythrocyte differentiation
GO:0034229 ethanolamine transport
GO:0035108 limb morphogenesis
GO:0035264 multicellular organism growth
GO:0042733 embryonic digit morphogenesis
GO:0043249 erythrocyte maturation
GO:0046620 regulation of organ growth
GO:0048536 spleen development
GO:0048704 embryonic skeletal system morphogenesis
GO:0055085 transmembrane transport
GO:0060323 head morphogenesis
GO:0097037 heme export
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qct, PDBe:8qct, PDBj:8qct
PDBsum8qct
PubMed38778100
UniProtQ9Y5Y0|FLVC1_HUMAN Heme transporter FLVCR1 (Gene Name=FLVCR1)

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