Structure of PDB 8q9u Chain A

Receptor sequence
>8q9uA (length=542) Species: 662548 (Variovorax sp. RA8) [Search protein sequence]
PRNIKAARGTTLRCKGWQQETILRLLENNIENGERPEDLVIYMNAAKAAR
DWDCFDAIVRTLKTMEADETLVVQSGKPVGLFRTHAFAPRVLLANGNVAG
RWAGDANMFELEKRGLTILPGMTAACWQYIGSQGIVQGTYQSFVSAAEQY
FGGSLAGRIILTAGAGGMGGAQPLAGKMAGAATLVVDVDPVSLERRLNTG
YLDVIATSVDDALARIRTLAAEREGGSVGIVGNAADVFEALHRKELRPDI
VTDQCMVDPYRGYVPSGLSPAEAAQLVRTDPEQALALAAATLARHARAML
RFRDDGAVVFEYGNTLRARSVAAGVPEAGELPSFVTLFIRPLFCRGIGPF
RWIAASGDPKDIAAIDGIIESTFAEGHMIRQWIPMARKYIQFQGLPARIG
WLGHGERSKLALLVNEAVADGRISAPIAFTRDHLDAGSVASPYAETEKMQ
DGSDAVSDWPLLNAMLACSNGASLVALHSNGDKSASAGQTAIADGTPMAA
FKLKSVLDADTGIGVIRYADAGYEVARETRALHGLGIEIGGG
3D structure
PDB8q9u Structure and Substrate Specificity of S -Methyl Thiourocanate Hydratase.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.49: urocanate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A Y48 M49 N50 G172 G173 M174 D193 V194 N239 A240 Q260 C261 M262 G268 Y269 V270 Y318 N320 F340 Y42 M43 N44 G166 G167 M168 D187 V188 N233 A234 Q254 C255 M256 G262 Y263 V264 Y312 N314 F334
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016153 urocanate hydratase activity
GO:0016829 lyase activity
Biological Process
GO:0006547 L-histidine metabolic process
GO:0006548 L-histidine catabolic process
GO:0019556 L-histidine catabolic process to glutamate and formamide
GO:0019557 L-histidine catabolic process to glutamate and formate

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Molecular Function
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Biological Process
External links
PDB RCSB:8q9u, PDBe:8q9u, PDBj:8q9u
PDBsum8q9u
PubMed38389448
UniProtA0A6P2DXK2

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