Structure of PDB 8q7e Chain A

Receptor sequence
>8q7eA (length=947) Species: 9606 (Homo sapiens) [Search protein sequence]
LMVPLRLQAYPEELIRQRHDGHPEYLIRWSVLKCEHILMWLSAPEVYANC
PGLLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYA
SIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAH
VLLSLSQQHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFS
LVKRYLCVTSLLDQLNSRGQRELEFSMAVGNLISELVRSMGWARPTRSIF
QPLYPLPYLQPTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLGEISVSVE
MAESLLQVLSSRFEGSTLNDLLNSQIYTKYLSVLRVITRLLDFPEAMVLP
WHEVLEPCLNCLSDSEIVQELTCFLHRLASHKDYAVVLCCLGAKEILSKV
LDKHGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQP
INIPFFDVFLRHLCQFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDHRRL
LQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSP
DAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPS
SSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPRYCKLYEHLQRAGSELF
GPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGGLIGGAP
GVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFSWLEGAVL
EQIGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEPSP
AISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQNHRR
LQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLSP
ELLLQALVPLTSGNGPLTLHEGVLRLHEPGSGEALWLIPPQAYLNVE
3D structure
PDB8q7e Noncanonical assembly, neddylation and chimeric cullin RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
ChainA
Resolution4.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A A1694 S1696 L1698 L1700 Q1753 W1754 T1755 R1759 A1760 E1761 A801 S803 L805 L807 Q852 W853 T854 R858 A859 E860
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007088 regulation of mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8q7e, PDBe:8q7e, PDBj:8q7e
PDBsum8q7e
PubMed38605244
UniProtQ8IWT3|CUL9_HUMAN Cullin-9 (Gene Name=CUL9)

[Back to BioLiP]