Structure of PDB 8q6e Chain A

Receptor sequence

>8q6eA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]

LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKL
GSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAK
VSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAIT
VWYFDADERARAKVKYLTG

3D structure

PDB

8q6e HIF prolyl hydroxylase 2 in complex with HIF2alpha-CODD

Chain

Resolution

1.37 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Q239 L240 V241 S242 R252 W258 D277 R281 N293 G294 R295 Y310 H313 V314 D315 P317 N318 R322 W389 F391 R396 Y403	Q52 L53 V54 S55 R65 W71 D90 R94 N106 G107 R108 Y123 H126 V127 D128 P130 N131 R135 W202 F204 R209 Y216
BS02	MG	A	T257 W258	T70 W71
BS03	MG	A	V338 G340	V151 G153
BS04	FE	A	H313 D315 H374	H126 D128 H187
BS05	AKG	A	Y310 H313 Y329 H374 V376 R383	Y123 H126 Y142 H187 V189 R196

External links

PDB	RCSB:8q6e, PDBe:8q6e, PDBj:8q6e
PDBsum	8q6e
PubMed
UniProt	Q9GZT9\|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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