Structure of PDB 8q6d Chain A

Receptor sequence

>8q6dA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]

PLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFT
DGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGK
LGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDA
KVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAI
TVWYFDADERARAKVKYLTG

3D structure

PDB

8q6d HIF prolyl hydroxylase 2 in complex with HIF2alpha-CODD

Chain

Resolution

1.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Q239 L240 V241 S242 R252 W258 D277 R281 N293 G294 R295 Y310 H313 V314 D315 P317 N318 R322 W389 F391 R396 K400	Q53 L54 V55 S56 R66 W72 D91 R95 N107 G108 R109 Y124 H127 V128 D129 P131 N132 R136 W203 F205 R210 K214
BS02	FE	A	H313 D315 H374	H127 D129 H188
BS03	AKG	A	Y310 H313 Y329 L343 H374 V376 R383	Y124 H127 Y143 L157 H188 V190 R197

External links

PDB	RCSB:8q6d, PDBe:8q6d, PDBj:8q6d
PDBsum	8q6d
PubMed
UniProt	Q9GZT9\|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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