Structure of PDB 8q43 Chain A

Receptor sequence

>8q43A (length=411) Species: 509193 (Thermoanaerobacter brockii subsp. finnii Ako-1) [Search protein sequence]

LVLIVGTNPLPNYVVGSHLKEKYDKFVLIYSEKNDKINQNSTYDYAKKLK
EHLNLNDKCIFLPLSDVSNSEKIINDLREKFHLNYTGGTKTMVVHIYNFL
KEFEGSYLDARDYKLVYDAISLKDTIKIDINTLLSIHLYEDIHFEFYDTY
SYKQKFVDSFDKISQEIEKAIKDDKGEDFVKWLEDPFRKIFKGENKLLEK
TAKFKKHIEKLLKDNDSSPIVKFNEKTPQFIWDILNAFPEGKKLNDGQKL
WIPDDKITNDNLSSRVKDTVEFLNGKWFEWYVYSQIKSELLDRKLKEGEH
FGISLKAQKKDSPYFALDIFLINGYQLIGISLTTSSTRELCKLKGFEVIH
RVRQIGGDESKAILITGMDKSKTEDLQKDLAYETGSTQKRFVVFGIDDWA
DIGSKICEEVF

3D structure

PDB

8q43 Substrate selectivity and catalytic activation of the type III CRISPR-associated ancillary nuclease Can2

Chain

Resolution

2.28 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R213 K217 E296 N299 G300 K301 Y339 A341 T358 T359 S360	R188 K192 E271 N274 G275 K276 Y314 A316 T333 T334 S335
BS02	rna	A	G11 T12 N13 P16 S36 T47 T99 G101 T102 K103 Y128 A131 E384 G410	G6 T7 N8 P11 S31 T42 T86 G88 T89 K90 Y107 A110 E359 G385
BS03	MN	A	D154 E324	D129 E299
BS04	MN	A	D343 L357	D318 L332

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:8q43, PDBe:8q43, PDBj:8q43
PDBsum	8q43
PubMed	38033326
UniProt	E8URK0

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