Structure of PDB 8q41 Chain A

Receptor sequence

>8q41A (length=427) Species: 509193 (Thermoanaerobacter brockii subsp. finnii Ako-1) [Search protein sequence]

EKVLVLIVGTNPLPNYVVGSHLKEKYDKFVLIYSEKNDKINQNSTYDYAK
KLKEHLNLNDKCIFLPLSDVSNSEKIINDLREKFPSEDFVEVHLNYTGGT
KTMVVHIYNFLKEKFIKFEGSYLDARDYKLVYDYSEEAISLKDTIKIDIN
TLLSIHLYEDIHFEFYDTYSYKQKFVDSFDKISQEIEKAIKDDKGEDFVK
WLEDPFRKIFKGENKLLEKTAKFKKHIEKLLSSPIVKFNEKTPQFIWDIL
NAFPEGKKLNDGQKLWIPDDKITNDNLSSRVKDTVEFLNGKWFEWYVYSQ
IKSELLDRKLKEGEHFGISLKAQKKDSPYFALDIFLINGYQLIGISLTTS
STRELCKLKGFEVIHRVRQIGGDESKAILITGMDKSKTEDLQKDLAYETG
STQKRFVVFGIDDWADIGSKICEEVFK

3D structure

PDB

8q41 Substrate selectivity and catalytic activation of the type III CRISPR-associated ancillary nuclease Can2

Chain

Resolution

2.38 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E209 R213 K217 N299 K301 P338 Y339 T358 T359 S360	E203 R207 K211 N289 K291 P328 Y329 T348 T349 S350
BS02	rna	A	G11 T12 N13 P16 S36 T47 T99 G101 T102 K103 Y128 L129 A131 R132 E384 T409 G410	G9 T10 N11 P14 S34 T45 T97 G99 T100 K101 Y122 L123 A125 R126 E374 T399 G400
BS03	MN	A	D343 L357	D333 L347

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:8q41, PDBe:8q41, PDBj:8q41
PDBsum	8q41
PubMed	38033326
UniProt	E8URK0

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