Structure of PDB 8q3s Chain A

Receptor sequence

>8q3sA (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]

PAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQ
GFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPP
GWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKL
RSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPR
KLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLT
RYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLP
STIMNHHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLM
ENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

3D structure

PDB

8q3s HsNMT1 in complex with both MyrCoA and GNCFSKAR inhibitor peptide

Chain

Resolution

1.78 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D183 D185 F188 F190 T282 Y296 H298 F311 S405 I469 G470 D471 G472 N473 Q496	D79 D81 F84 F86 T178 Y192 H194 F207 S301 I363 G364 D365 G366 N367 Q390
BS02	COA	A	Y117 Q118 F119 W120 Y180 V181 L248 C249 V250 R255 S256 A260 P261 A283	Y13 Q14 F15 W16 Y76 V77 L144 C145 V146 R151 S152 A156 P157 A179

External links

PDB	RCSB:8q3s, PDBe:8q3s, PDBj:8q3s
PDBsum	8q3s
PubMed
UniProt	P30419\|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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