Structure of PDB 8q3k Chain A

Receptor sequence
>8q3kA (length=1420) Species: 10498 (African swine fever virus BA71V) [Search protein sequence]
MEAGYAEIAAVQFNIAGDNDHKRQGVMEVTISNLFEGTLPAEGGIYDARM
GTTDHHYKCITCSHQRKQCMGHPGILQMHAPVLQPLFIAEIRRWLRVICL
NCGAPIVDLKRYEHLIRPKRLIEAASSQTEGKQCYVCKAVHPKIVKDSED
YFTFWVDQQGKIDKLYPQIIREIFSRVTYDTVVKLGRSKNSHPEKLVLKA
IQIPPISIRPGIRLGIQSFHDINNVIQYLVRKNLLIPKDLQIVRGQKIPL
NIDRNLQTIQQLYYNFLLDSVSTRPAPSIMRRLPRKEGRIRKSLLGSQVW
SISRSTICGNSDLHLDEVGYPISFARTLQVAETVQHYNINRLMPYFLNGK
RQYPGCSRVYKQITQSVHDIEGLKQDFRLEVGDILYRDVVTGDVAFFNRQ
PSLERSSIGVHRIVVLENPKISTFQMNVSACAWYNADFDGDQMNLWVPWS
VMSRVEAELLCSVRNWFISTKSSGPVNGQVQDSTVGSFLLTRTNTPMGKN
VMNKLHAMGLFQTTQTDPPCFANYSPTDLLDGKSVVSMLLKQTPINYQRA
PTWYSEVYAPYMHYNKQDISTQIRNGELIEGVLDKKAVGAGSSGGIYHLI
SRRYGPQQALKMIFATQQLALNYVRNAGFTVSTADMLLTPEAHQEVQEII
NKLLLESEEINNRLLHGDIMPPIGLTTHDFYEKLQLNALKFPDRILKPIM
NSINPETNGLFQMVATGAKGSNPNMIHIMAGIGQIEINTQRIQPQFSFGR
TLVYYPRFALEAQAYGFICNSYIAGLTSPEFIFGEMNGRFDLINKALSTS
STGYANRKAIFGLQSCIVDYYRRVSIDTRLVQQLYGEDGLDARQLETVRF
ETIMLSDQELEDKFKYTGIQSPLFEEEFSRLKKDRDKYRQIFLNVENFNF
SQLLTDVRQVPVNVASIVKNILLSSTSGVLPFDEKSILQKYAMVKTFCKN
LPYVFINNIQERLQTPIPVYLKRAAALMRMLIRIELATVKTLNITCEQMS
AILDLIRLQYTQSLINYGEAVGILAAQSVSEPLTQYMLDSHHRSNKSGIV
RPQEIFSAKPVEAEQSSEMLLRLKNPEVETNKTYAQEIANSIELITFERL
ILQWHLLYETYSSTKKNVMYPDFASDVEWMTDFLENHPLLQPPEDIANWC
IRLELNKTTMILKSISLESIINSLRAKHPNTYIMHSVENTASGIPIIIRI
YLRESAFRRSTNTRMATDEKIAVNVVDKLLNSTIRGIPGIKNANVVKLMR
HRVDAQGKLVRLDNIYAIKTNGTNIFGAMLDDNIDPYTIVSSSIGDTMEL
YGIEAARQKIISEIRTVMGDKGPNHRHLLMYADLMTRTGQVTSLEKAGLN
AREPSNVLLRMALSSPVQVLTDAAVDSAVNPIYGIAAPTLMGSVPRIGTM
YSDIIMDEKYITENYKSVDS
3D structure
PDB8q3k Structural characterization of the fully recombinant RNA polymerase from African Swine Fever Virus
ChainA
Resolution2.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C59 C62 C69 H72 C59 C62 C69 H72
BS02 ZN A C99 C102 C134 C137 C99 C102 C134 C137
BS03 MG A D457 D459 D461 D437 D439 D441
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q3k, PDBe:8q3k, PDBj:8q3k
PDBsum8q3k
PubMed38383525
UniProtP42486|RPB1_ASFB7 DNA-directed RNA polymerase RPB1 homolog (Gene Name=Ba71V-99)

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