Structure of PDB 8pz4 Chain A

Receptor sequence

>8pz4A (length=466) Species: 287 (Pseudomonas aeruginosa)

GSSHHHHHHSSGLVPRGSHMANSGEAPKNFGLDVKITGESENDRDLGTAP
GGTLNDIGIDLRPWAFGQWGDWSAYFMGQAVAATDTIETDTLQGREPDKS
YLAAREFWVDYAGLTAYPGEHLRFGRQRLREDSGQWQDTNIEALNWSFET
TLLNAHAGVAQRFSEYRTDLDELAPEDKDRTHVFGDISTQWAPHHRIGVR
IHHADDSGHLRRPGEEVDNLDKTYTGQLTWLGIEATGDAYNYRSSMPLNY
WASATWLTGDRDNLTTTTVDDRRIATGKQSGDVNAFGVDLGLRWNIDEQW
KAGVGYARGSGGGKDGEEQFQQTGLESNRSNFTGTRSRVHRFGEAFRGEL
SNLQAATLFGSWQLREDYDASLVYHKFWRVDDDSDIGTSGINAALQPGEK
DIGQELDLVVTKYFKQGLLPASMSQYVDEPSALIRFRGGLFKPGDAYGPG
TDSTMHRAFVDFIWRF

3D structure

• PDB: 8pz4 Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
• Chain: A
• Resolution: 1.77 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	A125 T128 Y130 E133	A112 T115 Y117 E120
BS02	CA	A	D44 D46 A50 P51 G52	D43 D45 A49 P50 G51
BS03	78M	A	W70 A75 F77 W121 F137	W69 A74 F76 W108 F124
BS04	78M	A	W159 F197 I214 H216	W146 F184 I201 H203
BS05	78N	A	Y381 V423 I447	Y368 V410 I434
BS06	78N	A	W307 F372	W294 F359
BS07	78N	A	P64 Q80 A81 R180 L183 D184	P63 Q79 A80 R167 L170 D171

Gene Ontology

Biological Process

• GO:0042121 alginic acid biosynthetic process

Cellular Component

• GO:0009279 cell outer membrane

External links

• PDB: RCSB:8pz4, PDBe:8pz4, PDBj:8pz4
• PDBsum: 8pz4
• PubMed: 37828292
• UniProt: P18895|ALGE_PSEAE Alginate production protein AlgE (Gene Name=algE)