Structure of PDB 8px0 Chain A

Receptor sequence

>8px0A (length=121) Species: 9913 (Bos taurus)

KETAAAKFERQHMDSSTSSSNYCNQMMKSRNLTKDRCKPVNTFVHESLAD
VQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQAN
KHIIVACEGNPYVPVHFDASV

3D structure

• PDB: 8px0 Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0U	A	Q11 H12 K41 V43 N44 T45 H119 F120	Q11 H12 K38 V40 N41 T42 H116 F117

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:8px0, PDBe:8px0, PDBj:8px0
• PDBsum: 8px0
• PubMed: 37828292
• UniProt: P61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)