Structure of PDB 8pwn Chain A

Receptor sequence
>8pwnA (length=389) Species: 562,9606 [Search protein sequence]
APPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLA
AADILVGVLAIPFAITISTGFCAACHGCLFIACFVLVLAQSSIFSLLAIA
IDRYIAIAIPLRYNGLVTGTRAAGIIAICWVLSFAIGLTPMLGWNNCGQP
KEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLR
IFAAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQ
KADFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLE
RARSTLQKEVHAAKSAAIIAGLFALCWLPLHIINCFTFFCPDCSHAPLWL
MYLAIVLAHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL
3D structure
PDB8pwn Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TEP A F193 E194 L370 N374 F169 E170 L330 N334
BS02 CLR A A97 G101 I105 A73 G77 I81
BS03 CLR A L368 F376 S384 L328 F336 S344
BS04 CLR A F376 F379 C380 F336 F339 C340
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:8pwn, PDBe:8pwn, PDBj:8pwn
PDBsum8pwn
PubMed37828292
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

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