Structure of PDB 8pwm Chain A

Receptor sequence
>8pwmA (length=238) Species: 7955 (Danio rerio) [Search protein sequence]
MLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVSY
SIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSW
SCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAI
CLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLA
DLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV
3D structure
PDB8pwm Novel Des-C-Ring and Aromatic-D-Ring analogs Acting as Potent Agonists of the Vitamin D Receptor (VDR)
ChainA
Resolution2.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K274 R280 Q287 I288 K292 P442 L443 E446 V447 E451 V452 K60 R66 Q73 I74 K78 P228 L229 E232 V233 E237 V238
BS02 HXI A Y175 L255 V262 S265 R302 S303 S306 W314 V328 H333 L341 H423 Y427 L430 F448 Y21 L41 V48 S51 R88 S89 S92 W100 V114 H119 L127 H209 Y213 L216 F234
External links
PDB RCSB:8pwm, PDBe:8pwm, PDBj:8pwm
PDBsum8pwm
PubMed
UniProtQ9PTN2|VDRA_DANRE Vitamin D3 receptor A (Gene Name=vdra)

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