Structure of PDB 8pw9 Chain A

Receptor sequence
>8pw9A (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRL
NIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRII
HWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIER
LSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGI
IS
3D structure
PDB8pw9 Crystal structure of the human METTL3-METTL14 in complex with a bisubstrate analogue (BA1)
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.348: mRNA m(6)A methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H9D A D377 I378 D395 P397 P405 Y406 L409 S511 F534 R536 N549 Q550 D10 I11 D28 P30 P38 Y39 L42 S138 F161 R163 N176 Q177
Gene Ontology
Molecular Function
GO:0001734 mRNA m(6)A methyltransferase activity
Biological Process
GO:0001510 RNA methylation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pw9, PDBe:8pw9, PDBj:8pw9
PDBsum8pw9
PubMed38470714
UniProtQ86U44|MTA70_HUMAN N6-adenosine-methyltransferase catalytic subunit (Gene Name=METTL3)

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