Structure of PDB 8pu0 Chain A

Receptor sequence
>8pu0A (length=1157) Species: 9606 (Homo sapiens) [Search protein sequence]
MRNLKLFRTLEFRDIQGPGNPQCFSLRTEQGTVLIGSEHGLIEVDPVSRE
VKNEVSLVAEGFLPEDGSGRIVGVQDLLDQESVCVATASGDVILCSLSTQ
QLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPILEQQIHQ
DDFGESKFITVESALPWDDHRPQVTWRGDGQFFAVSVVCPETGARKVRVW
NREFALQSTSEPVAGLGPALAWKPSGSLIASTQDKPNQQDIVFFEKNGLL
HGHFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLQKTCVQLWTVGNYHWY
LKQSLSFSTCGKSKIVSLMWDPVTPYRLHVLCQGWHYLAYDWHWTTDRSV
GDNSSDLSNVAVIDGNRVLVTVFRQTVVPPPMCTYQLLFPHPVNQVTFLA
HPQKSNDLAVLDASNQISVYKCGDCPSADPTVKLGAVGGSGFKVCLRTPH
LEKRYKIQFPLKLGLLTWIEEDVFLAVSHSEFSPRSVIHHLTAASSEMDE
EHGQLNVSSSAAVDGVIISLCCNSKTKSVVLQLADGQIFKYLWESPSLAI
KPWKNSGGFPVRFPYPCTQTELAMIGEEECVLGLTDRCRFFINDIEVASN
ITSFAVYDEFLLLTTHSHTCQCFCLRDASFKTLQAGLSSNHVSHGEVLRK
VERGSRIVTVVPQDTKLVLQMPRGNLEVVHHRALVLAQIRKWLDKLMFKE
AFECMRKLRINLNLIYDHNPKVFLGNVETFIKQIDSVNHINLFFTELKEE
DVTKTMYPAPVGNKIDLVCDAMRAVMESINPHKYCLSILTSHVKKTTPEL
EIVLQKVHELQGNADAVSAEEALKYLLHLVDVNELYDHSLGTYDFDLVLM
VAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGP
EYFPECLNLIKDKNLYNEALKLYSPSSQQYQDISIAYGEHLMQEHMYEPA
GLMFARCGAHEKALSAFLTCGNWKQALCVAAQLNFTKDQLVGLGRTLAGK
LVEQRKHIDAAMVLEECAQDYEEAVLLLLEGAAWEEALRLVYKYNRLDII
ETNVKPSILEAQKNYMAFLDSQTATFSRHKKRLLVVEALSEVVQNTENLK
DEVYHILKVLFLFEFDEQGRELQKAFEDTLQLMERSLPEIWPPKINRRTQ
WKLSLLD
3D structure
PDB8pu0 Cryo-EM structure of human Elp123 in complex with tRNA, desulpho-CoA, 5'-deoxyadenosine and methionine
ChainA
Resolution4.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R1133 H1134 R1078 H1079
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006417 regulation of translation
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033588 elongator holoenzyme complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pu0, PDBe:8pu0, PDBj:8pu0
PDBsum8pu0
PubMed38750017
UniProtO95163|ELP1_HUMAN Elongator complex protein 1 (Gene Name=ELP1)

[Back to BioLiP]