Structure of PDB 8pt2 Chain A

Receptor sequence

>8pt2A (length=417) Species: 1549864 (Tilapia lake virus) [Search protein sequence]

MDSRFAQLTGVFCDDFTYSEGSRRFLSSYSTVERRPGVPVEGDCYDCLKN
KWIAFELEGQPRKFPKATVRCILNNDATYVCSEQEYQQICKVQFKDYLEI
DGVVKVGHKASYDAELRERLLELPHPKSGPKPRIEWVAPPRLADISKETA
ELKRQYGFFECSKFLACGEECGLDQEARELILNEYARDREFEFRNGGWIQ
RYTVASHKPATQKILPLPASAPLARELLMLIARSTTQAGKVLHSDNTSIL
AVPVMRDSGKHSKRRPTASTHHLVVGLSKPGCEHDFEFDGYRAAVHVMHL
DPKQSANIGEQDFVSTREIYKLDMLELPPISRKGDLDRASGLETRWDVIL
LLECLDSTRVSQAVAQHFNRHRLALSVCKDEFRKGYQLASEIRGTIPLSS
LYYSLCAVRLRMTVHPF

3D structure

PDB

8pt2 Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.

Chain

Resolution

2.59 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	Y202 V204 A205 H207 K208 A210 V254 K263 T267 S269 T270 H271 H299 L300 Q304 L355 S357 R393 G394 P397	Y202 V204 A205 H207 K208 A210 V254 K263 T267 S269 T270 H271 H299 L300 Q304 L355 S357 R393 G394 P397
BS02	rna	A	Q175 M229 R233 T235 T236 Q237 H243 S244 D245 H261 S262 R264 R265 T267 T270 H272	Q175 M229 R233 T235 T236 Q237 H243 S244 D245 H261 S262 R264 R265 T267 T270 H272
BS03	ZN	A	C161 C282 H284 H296	C161 C282 H284 H296

External links

PDB	RCSB:8pt2, PDBe:8pt2, PDBj:8pt2
PDBsum	8pt2
PubMed	38066000
UniProt	A0A142I7Z3

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