Structure of PDB 8ps1 Chain A

Receptor sequence
>8ps1A (length=1584) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFNTERVVEIGPS
PTLAGMAQRTLKNKYESYDAALSLHREILCYSKDAKEIYYTPDPLEEITK
DHKVLARQQLQVLARYLKMDLDNGERKFLKEKDTVAELQAQLDYLNAELG
EFFVNGVATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDREVV
SEAINIMNRSNDALIKFMEYHISNTDETKGENYQLVKTLGEQLIENCKQV
LDVDPVYKDVAKPTGPKTAIDKNGNITYSEEPREKVRKLSQYVQEMALGG
PITKESEDALDKDSTKEVASLPNKSTISKTVSSTIPRETIPFLHLRKKTP
AGDWKYDRQLSSLFLDGLEKAAFNGVTFKDKYVLITGAGKGSIGAEVLQG
LLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKGSTLIVVPFNQGSKQDV
EALIEFIYDTEKNGGLGWDLDAIIPFAAIPEQGIELEHIDSKSEFAHRIM
LTNILRMMGCVKKQKSARGIETRPAQVILPMSPNHGTFGGDGMYSESKLS
LETLFNRWHSESWANQLTVCGAIIGWTRGTGLMSANNIIAEGIEKMGVRT
FSQKEMAFNLLGLLTPEVVELCQKSPVMADLNGGLQFVPELKEFTAKLRK
ELVETSEVRKAVSIETALEHKVVNGNSADAAYAQVEIQPRANIQLDFPEL
KPYKQVKQIAPAELEGLLDLERVIVVTGFAEVGPWGSARTRWEMEAFGEF
SLEGCVEMAWIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKDVKAKYET
SILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEEDLEPFEASKETAEQFK
HQHGDKVDIFEIPETGEYSVKLLKGATLYIPKALRFDRLVAGQIPTGWNA
KTYGISDDIISQVDPITLFVLVSVVEAFIASGITDPYEMYKYVHVSEVGN
CSGSGMGGVSALRGMFKDRFKDEPVQNDILQESFINTMSAWVNMLLISSS
GPIKTPVGACATSVESVDIGVETILSGKARICIVGGYDDFQEEGSFEFGN
MKATSNTLEEFEHGRTPAEMSRPATTTRNGFMEAQGAGIQIIMQADLALK
MGVPIYGIVAMAATATDKIGRSVPAPGKGILTTAREHHSSVKYASPNLNM
KYRKRQLVTREAQIKDWVENELEALKLEAEEIPSEDQNEFLLERTREIHN
EAESQLRAAQQQWGNDFYKRDPRIAPLRGALATYGLTIDDLGVASFHGTS
TKANDKNESATINEMMKHLGRSEGNPVIGVFQKFLTGHPKGAAGAWMMNG
ALQILNSGIIPGNRNADNVDKILEQFEYVLYPSKTLKTDGVRAVSITSFG
FGQKGGQAIVVHPDYLYGAITEDRYNEYVAKVSAREKSAYKFFHNGMIYN
KLFVSKEHAPYTDELEEDVYLDPLARVSKDKKSGSLTFNSKNIQSKDSYI
NANTIETAKMIENMTKEKVSNGGVGVDVELITSINVENDTFIERNFTPQE
IEYCSAQPSVQSSFAGTWSAKEAVFKSLGVALKDIEIVRVNKNAPAVELH
GNAKKAAEEAGVTDVKVSISHDDLQAVAVAVSTK
3D structure
PDB8ps1 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I.
2.3.1.86: fatty-acyl-CoA synthase system.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G682 S687 T707 S708 N738 Q739 F771 A772 A773 I774 P825 Y839 K843 I869 T872 T875 G876 L877 M878 G387 S392 T412 S413 N443 Q444 F476 A477 A478 I479 P530 Y544 K548 I574 T577 T580 G581 L582 M583
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004312 fatty acid synthase activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004321 fatty-acyl-CoA synthase activity
GO:0005515 protein binding
GO:0008897 holo-[acyl-carrier-protein] synthase activity
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0042759 long-chain fatty acid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005835 fatty acid synthase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ps1, PDBe:8ps1, PDBj:8ps1
PDBsum8ps1
PubMed37949058
UniProtP19097|FAS2_YEAST Fatty acid synthase subunit alpha (Gene Name=FAS2)

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