Structure of PDB 8pqi Chain A

Receptor sequence
>8pqiA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLS
RSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK
SGPIYIIIEYCFYGDLVNYLHKNRDSFLGLTLLDLLSFTYQVARGMEFLA
SKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMTFLPVKWMAPESIFDN
LYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDH
ATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDF
3D structure
PDB8pqi Avapritinib-based SAR studies reveal a binding pocket in KIT and PDGFRA
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9OO A G602 G605 K606 V607 K627 M628 L629 Y676 C677 G680 L825 D836 G36 G39 K40 V41 K61 M62 L63 Y110 C111 G114 L165 D176
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8pqi, PDBe:8pqi, PDBj:8pqi
PDBsum8pqi
PubMed38167404
UniProtP16234|PGFRA_HUMAN Platelet-derived growth factor receptor alpha (Gene Name=PDGFRA)

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