Structure of PDB 8pqc Chain A

Receptor sequence
>8pqcA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
NNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSD
AAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGP
TLVITEYCCYGDLLNFLRRKRDEFVPYKDFLTLEHLLSFSYQVAKGMAFL
ASKNCIHRDLAARNILLTHGNITKICDFGLARDIKSNYVDKGNARLPVKW
MAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE
GFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISEST
3D structure
PDB8pqc Avapritinib-based SAR studies reveal a binding pocket in KIT and PDGFRA
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9OO A L595 G596 G598 G601 K602 V603 K623 M624 L625 Y672 C673 G676 L799 D810 L30 G31 G33 G36 K37 V38 K58 M59 L60 Y107 C108 G111 L166 D177
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8pqc, PDBe:8pqc, PDBj:8pqc
PDBsum8pqc
PubMed38167404
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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