Structure of PDB 8pqb Chain A

Receptor sequence
>8pqbA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
NYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLMTVAV
KMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEY
CCYGDLLNFLRRKRDEFVPYKDFLTLEHLLSFSYQVAKGMAFLASKNCIH
RDLAARNILLTHGNITKICDFGLARDIKRLPVKWMAPESIFNSVYTFESD
VWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYD
IMKTCWDADPDKRPTFKQIVQDIEKQISES
3D structure
PDB8pqb Avapritinib-based SAR studies reveal a binding pocket in KIT and PDGFRA
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9XO A L595 G596 G601 K602 V603 K623 M624 L625 Y672 C673 G676 L799 L29 G30 G35 K36 V37 K51 M52 L53 Y100 C101 G104 L159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8pqb, PDBe:8pqb, PDBj:8pqb
PDBsum8pqb
PubMed38167404
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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