Structure of PDB 8ppi Chain A

Receptor sequence
>8ppiA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQLGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHG
VVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRK
DMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIK
KADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEV
SEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWE
EGNREDGYLLGLDNLIGILASLAER
3D structure
PDB8ppi Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 69I A K264 R285 K312 Y315 R319 K419 K78 R99 K126 Y129 R133 K233
BS02 ATP A F198 K209 D250 L251 D262 I415 D416 F12 K23 D64 L65 D76 I229 D230
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppi, PDBe:8ppi, PDBj:8ppi
PDBsum8ppi
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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