Structure of PDB 8ppf Chain A

Receptor sequence
>8ppfA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERD
GESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKK
MLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGS
CSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFR
RHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNRE
DGYLLGLDNLIGILASLAER
3D structure
PDB8ppf Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A H185 F198 K209 Q249 D250 L251 D262 I415 D416 H3 F7 K18 Q58 D59 L60 D71 I224 D225
BS02 6II A K264 R285 M288 K291 K312 Y315 R319 K419 K73 R94 M97 K100 K121 Y124 R128 K228
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppf, PDBe:8ppf, PDBj:8ppf
PDBsum8ppf
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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